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> Hemodialysis

Drug Dosing in Hemodialysis

> Clinical Tools

Potassium Chloride Products 

Stepwise Approach to Uremic Pruritus 

Appendix: Hydroxyzine (Atarax®) and Risk of QT Interval Prolongation and Torsades de Pointes 

> Peritoneal Dialysis

Compatibility of Common Drugs With Peritoneal Dialysis Solutions

(Prepare immediately prior to use)
DRUG PD SOLUTION
DIANEAL EXTRANEAL NUTRINEAL PHYSIONEAL
         
Calcium gluconate Yes Unknown Unknown Unknown
Cefazolin Yes Yes Unknown Yes
Cefazolin+ Ceftazidime Yes Unknown Unknown Unknown
Cefazolin+ Gentamicin Yes Unknown Unknown Unknown
Cefazolin+ Gentamicin+ Heparin Yes Unknown Unknown Unknown
Cefazolin+ Heparin Yes Unknown Unknown Unknown
Cefazolin+ Insulin Yes* Unknown Unknown Unknown
Cefazolin+ Heparin+ Insulin Yes* Unknown Unknown Unknown
Cefazolin+ Tobramycin Yes* Unknown Unknown Unknown
Ceftazidime Yes Yes Unknown Unknown
Ceftazidime+ Heparin Yes Unknown Unknown Unknown
Ceftazidime+ Tobramycin Yes Unknown Unknown Unknown
Ceftazidime+ Vancomycin Yes Unknown Unknown Unknown
Ceftazidime+ Vancomycin+ Heparin Yes Unknown Unknown Unknown
Erythromycin Yes Unknown Unknown Unknown
Fluconazole Yes Unknown Unknown Unknown
Gentamicin Yes Yes Yes Yes
Gentamicin+ Heparin Yes Unknown Unknown Unknown
Gentamicin+ Insulin Yes* Yes Unknown Unknown
Gentamicin+ Heparin+ Insulin Yes* Unknown Unknown Unknown
Gentamicin+ Vancomycin Yes Yes Unknown Unknown
Gentamicin+ Vancomycin+ Insulin Unknown Yes Unknown Unknown
Heparin Yes Yes Yes Yes
Heparin+ Insulin Yes* Yes Yes Unknown
Insulin Yes Yes Yes Yes
Metoclopramide Yes Unknown Unknown Unknown
Potassium chloride Yes Yes up to4 meq/L Unknown Unknown
Sodium bicarbonate Yes Unknown Unknown In product
Tobramycin Yes Unknown Unknown Yes
Tobramycin+ Heparin Yes Unknown Unknown Unknown
Tobramycin+ Insulin Yes* Unknown Unknown Unknown
Tobramycin+ Heparin+ Insulin Yes* Unknown Unknown Unknown
Tobramycin+ Vancomycin Yes Unknown Unknown Unknown
Vancomycin Yes Yes Yes Yes
Vancomycin+ Heparin Yes Yes Unknown Unknown
Vancomycin+ Insulin Yes* Yes Unknown Unknown
Vancomycin+ Heparin+ Insulin Yes* Yes Unknown Unknown

*Data on compatibility is based on current practice.
Version 1 – Pharmacy Document
Department of Pharmacy, SBGH
May, 2005

References

Bailie GR, Kane MP. Stability of drug additives to peritoneal dialysate. Perit Dial Int 1995; 15:328-35.
Baxter Physioneal Monograph.
Baxter Study Tables, faxed May 28, 2003.
Benz RL, Schleifer CR, et al. Successful treatment of postparathyroidectomy hypocalcemia using continuous ambulatory intraperitoneal calcium (CAIC) therapy. Perit Dial Int 1989; 9:285-8.
Dahl NV, Foote EF, et al. Pharmacokinetics of intraperitoneal fluconazole during continuous cycling peritoneal dialysis. Ann Pharmacother 1998; 32:1284-9
Dorval M, Legault L, et al. Practical aspects of the addition of sodium bicarbonate to peritoneal dialysate. Perit Dial Int 2000; 20(6):791-3.
Keane WF, Bailie GR, et al. Adult peritoneal dialysis-related peritonitis treatment recommendations: 2000 update. Perit Dial Int 2000; 20(4): 396-411.
Nephrology Pharmacy Associates. Peritoneal Dialysis 2004 – A Guide to Medication Use.
Sewell DL, Golper TA, et al. Stability of single and combination antimicrobial agents in various peritoneal dialysates in the presence of insulin and heparin. Am J Kidney Dis 1983; 3:209-12.

> CKD Patients Not on Dialysis

Kidney Failure Risk Calculation

> Useful Links

Calculators/Risk Assessment Tools

Cockcroft and Gault

MDRD Equation

GFR Calculator

Stroke Prevention in Atrial Fibrillation Risk Tool (SPARC Tool)

CVD Risk/Benefit Calculator

FRAX (Fracture Risk Assessment Tool)

 

Drug Information

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Health Canada Drug Product Database

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Saskatchewan Online Formulary Database

RxFiles (Saskatchewan)

Dalhousie Pharmacy Drug Information Resources

Eprex® (epoetin alpha) Product Monograph

Ferrlecit Product Monograph

 

External Guidelines and Clinical Tools

BC Renal Agency

Canadian Society of Nephrology Guidelines

KDIGO Guidelines 

National Kidney Foundation –  KDOQI Guidelines

Drug Prescribing in Renal Failure 4th ed.

Choosing Wisely Canada Recommendations

Therapeutics Initiative Therapeutics Letter 

REFRAME Health Lab (Dr. Mike Evans) Failing Kidneys and Different Treatment Options

Hypertension, Dialysis and Clinical Nephrology (HDCN)

Medscape Nephrology

NIH National Institute of Diabetes and Digestive and Kidney Diseases (Kidney Disease)

National Kidney Disease Education Program (NKEDP) 

 

Pharmacist Links

WRHA Pharmacy Insite

DPIN Login

Manitoba Pharmacare Formulary Drug Lookup

Guide for Pharmacy Benefits: Non-insured Health Benefits 2017

University of Manitoba Library: Pharmacy Guide

CSHP Manitoba Branch

Renal Pharmacists Network

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