Compatibility of Common Drugs With Peritoneal Dialysis Solutions

Compatibility of Common Drugs With Peritoneal Dialysis Solutions

(Prepare immediately prior to use)

*Data on compatibility is based on current practice.

DRUGPD SOLUTION
DIANEALEXTRANEALNUTRINEALPHYSIONEAL
Calcium gluconateYesUnknownUnknownUnknown
CefazolinYesYesUnknownYes
Cefazolin+ CeftazidimeYesUnknownUnknownUnknown
Cefazolin+ GentamicinYesUnknownUnknownUnknown
Cefazolin+ Gentamicin+ HeparinYesUnknownUnknownUnknown
Cefazolin+ HeparinYesUnknownUnknownUnknown
Cefazolin+ InsulinYes*UnknownUnknownUnknown
Cefazolin+ Heparin+ InsulinYes*UnknownUnknownUnknown
Cefazolin+ TobramycinYes*UnknownUnknownUnknown
CeftazidimeYesYesUnknownUnknown
Ceftazidime+ HeparinYesUnknownUnknownUnknown
Ceftazidime+ TobramycinYesUnknownUnknownUnknown
Ceftazidime+ VancomycinYesUnknownUnknownUnknown
Ceftazidime+ Vancomycin+ HeparinYesUnknownUnknownUnknown
ErythromycinYesUnknownUnknownUnknown
FluconazoleYesUnknownUnknownUnknown
GentamicinYesYesYesYes
Gentamicin+ HeparinYesUnknownUnknownUnknown
Gentamicin+ InsulinYes*YesUnknownUnknown
Gentamicin+ Heparin+ InsulinYes*UnknownUnknownUnknown
Gentamicin+ VancomycinYesYesUnknownUnknown
Gentamicin+ Vancomycin+ InsulinUnknownYesUnknownUnknown
HeparinYesYesYesYes
Heparin+ InsulinYes*YesYesUnknown
InsulinYesYesYesYes
MetoclopramideYesUnknownUnknownUnknown
Potassium chlorideYesYes up to4 meq/LUnknownUnknown
Sodium bicarbonateYesUnknownUnknownIn product
TobramycinYesUnknownUnknownYes
Tobramycin+ HeparinYesUnknownUnknownUnknown
Tobramycin+ InsulinYes*UnknownUnknownUnknown
Tobramycin+ Heparin+ InsulinYes*UnknownUnknownUnknown
Tobramycin+ VancomycinYesUnknownUnknownUnknown
VancomycinYesYesYesYes
Vancomycin+ HeparinYesYesUnknownUnknown
Vancomycin+ InsulinYes*YesUnknownUnknown
Vancomycin+ Heparin+ InsulinYes*YesUnknownUnknown

Version 1 – Pharmacy Document

Department of Pharmacy, SBGH

May, 2005

References

  • Bailie GR, Kane MP. Stability of drug additives to peritoneal dialysate. Perit Dial Int 1995; 15:328-35.
  • Baxter Physioneal Monograph.
  • Baxter Study Tables, faxed May 28, 2003.
  • Benz RL, Schleifer CR, et al. Successful treatment of postparathyroidectomy hypocalcemia using continuous ambulatory intraperitoneal calcium (CAIC) therapy. Perit Dial Int 1989; 9:285-8.
  • Dahl NV, Foote EF, et al. Pharmacokinetics of intraperitoneal fluconazole during continuous cycling peritoneal dialysis. Ann Pharmacother 1998; 32:1284-9
  • Dorval M, Legault L, et al. Practical aspects of the addition of sodium bicarbonate to peritoneal dialysate. Perit Dial Int 2000; 20(6):791-3.
  • Keane WF, Bailie GR, et al. Adult peritoneal dialysis-related peritonitis treatment recommendations: 2000 update. Perit Dial Int 2000; 20(4): 396-411.
  • Nephrology Pharmacy Associates. Peritoneal Dialysis 2004 – A Guide to Medication Use.
  • Sewell DL, Golper TA, et al. Stability of single and combination antimicrobial agents in various peritoneal dialysates in the presence of insulin and heparin. Am J Kidney Dis 1983; 3:209-12.